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Activated through the antibiotic rifampicin and different plant metabolites, like hyperforin, guggulipid, colupulone, and isoflavones. Response to unique ligands is species-precise. Activated by The natural way occurring steroids, for instance pregnenolone and progesterone. Binds to your response element from the promoters of the CYP3A4 and ABCB1/M